yihai.cao@ki.se
July 1978 – July 1983
Bachelor’s Degree: Shandong Medical College, Major in Clinical Medicine
1983
Master’s Degree: Shandong University, Qilu Medical School,
1993
Doctoral Degree: Karolinska Institute, Stockholm, Sweden, Major in Clinical Medicine and Molecular Biophys
2006
hM.D. Copenhagen University, Medicine, Copenhagen, Denmark
1993 – 1996
Postdoc Research Fellow and Instructor, Department of Surgery and Cellular Biology, Harvard Medical School, Children's Hospital, Boston, Massachusetts, USA
1996 - 1998
Senior Research Associate, Karolinska Institute, Stockholm, Sweden
1998 - 2004
Assistant Professor, Karolinska Institutet, Stockholm, Sweden
2001
Lectureship, Karolinska Institutet, Swedish Research Council, Stockholm, Sweden
2004 – Present
Full professor at the Department of Microbiology, Tumor and Cell Biology,Karolinska Institutet, Stockholm, Sweden
Being trained as a medical doctor and a basic research scientist, Cao Yihai and his team pursues basic and translational research with emphasis on clinical implications. He has made seminal contributions to several medical fields. These include discovery of novel molecules and mechanistic studies of signaling molecules targeting the pathological vasculature as novel therapeutic approaches for treatment of cancer, ocular disease therapy, obesity and diabetic and cardiovascular diseases.
(1) Dedicated to mechanistic studies of vascular neovascularization in metabolic, oncologic, cardiovascular, and ophthalmic diseases
1. Fulbright research fellow award, USA, 1993.
2. Human Frontier Science Program postdoctoral grant award, France, 1993.
3. Eric Fernström Prize, one of the most prestigious mediccine prizes in Nordic countries, 2003.
4. Distinguished professor award at the Karolinska Institute, 2010.
5. European Research Council Advanced Grant (ERC-AdG) 2010.
6. Outstanding scientist at the Karolinska Institute assessed by international panel experts, 2012.
7. The Dr. Axel Hirsch Prize for medicine, one of the most prestigious international prizes in Sweden, 2013.
8. NOVO Nordisk Advanced award, Denmark, 2014.
9. Member of the European Academy of Sciences and Arts (EASA), 2017.
10. Member of the Academy of Europe (Academia Europaea, AE), 2018.
11. Member of the National Academy of Inventors (NAI) USA, 2018.
12. Member of the American Institute of Medicine and Biological Engineering (AIMBE)
13. Member of the Chinese Academy of Engineering (CAE), 2019
FUNDING
2022-2025 Principal Investigator, Novo Nordisk Research grant.
2022-2027 Co-Principal Investigator. EU Consortium grant.
2021-2025 Co-Principal Investigator. Sweden-China joint grant
2021-2025 Co-Principal Investigator. Hong Kong-Oxford-KI grant.
2021-2025 Principal Investigator, the Swedish Research Council.
2021-2023 Principal Investigator, the Swedish Cancer Foundation.
2018-2020 Principal Investigator, the Swedish Cancer Foundation.
2019-2021 Principal Investigator, KI-Strategic research area grant.
2019-2024 Principal Investigator Swedish Research Council.
2015-2021 Co-Principal Investigator Knut Alice Wallenberg grant.
2014-2020 Principal Investigator Novo Nordisk Advanced grant.
2010-2014 Principal Investigator ERC-advanced grant.
2010-2015 Principal Investigator Distinguished professor award, Karolinska Institutet.
2012-2015 Principal Investigator Swedish Research Council.
2012-2014 Principal Investigator Swedish Cancer Foundation.
2012-2014 Principal Investigator Torste Söderberg Foundation.
2006-2008 Principal Investigator Heart and Lung Foundation.
2010-2014 Co-applicant EU FP6 (Metoxia).
2006-2008 Co-applicant EU FP6 (Vascuplug).
2006-2008 Co-applicant EU FP6 (Angiotargeting).
2001-2004 Principal Investigator Human Frontier Science Program (HFSP).
1. Takahiro Seki# , Yunlong Yang#, Xiaoting Sun, Sharon Lim, Sisi Xie, Ziheng Guo, Wenjing Xiong, Masashi Kuroda, Hiroshi Sakaue, Kayoko Hosaka, Xu Jing, Masahito Yoshihara, Lili Qu, Xin Li, Yuguo Chen, Yihai Cao*. Brown-fat-mediated tumour suppression by cold-altered global metabolism. Nature, 2022;608(7922):421-428.. （通讯作者）
2. Hideki Iwamoto, Mitsuhiko Abe, Yunlong Yang, Takahiro Seki, Masaki Nakamura, Kayoko Hosaka, Sharon Lim, Takuji Torimura, Yongtian Lu, Guohui Nie and Yihai Cao Antiangiogenic drug-triggered lipid-dependent metabolic reprograming confers drug resistance, Cell Metabolism, 2018; 28(1):104-117. （通讯作者）
3. Daniel Martinez Molina 1, Rozbeh Jafari, Marina Ignatushchenko, Takahiro Seki, E Andreas Larsson, Chen Dan, Lekshmy Sreekumar, Yihai Cao, Pär Nordlund. Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay. Science. 2013 Jul 5;341(6141):84-7. （通讯作者）
4. Mei Dong1, Xiaoyan Yang, Sharon Lim, Ziquan Cao, Jennifer Honek, Huixia Lu, Cheng Zhang, Takahiro Seki, Kayoko Hosaka, Eric Wahlberg, Jianmin Yang, Lei Zhang, Toste Länne, Baocun Sun, Xuri Li, Yizhi Liu, Yun Zhang, Yihai Cao. Cold exposure promotes atherosclerotic plaque growth and instability via UCP1-dependent lipolysis. Cell metabolism. 2013;18(1):118-29. （通讯作者）
5. Yuan Xue, Sharon Lim, Yunlong Yang, Zongwei Wang, Lasse Dahl Ejby Jensen, Eva-Maria Hedlund, Patrik Andersson, Masakiyo Sasahara, Ola Larsson, Dagmar Galter, Renhai Cao, Kayoko Hosaka, Yihai Cao. PDGF-BB modulates hematopoiesis and tumor angiogenesis by inducing erythropoietin production in stromal cells. Nature medicine, 2011, 18(1), 100-110. （通讯作者）
6. Renhai Cao, Ebba Bråkenhielm, Robert Pawliuk, David Wariaro, Mark J Post, Eric Wahlberg, Philippe Leboulch, Yihai Cao. Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2. Nature medicine, 2003, 9(5), 604–613. （通讯作者）
7. Yihai Cao and Renhai Cao. Angiogenesis inhibited by drinking tea. Nature. 1999;398(6726):381. （第一作者）
8. Cheng H, Cao Y, Olson L. Spinal cord repair in adult paraplegic rats: partial restoration of hind limb function. Science. 1996 ;273(5274):510-3. （第二作者）
