wangzhao@ojlab.ac.cn
2013-2017 Doctor of Veterinary Preventive Medicine, Huazhong Agricultural University
2010-2013 Master of Veterinary Medicine, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences
2006-2010 Bachelor of Animal Medicine, Qingdao Agricultural University
2023.11-present Principal Investigator OuJiang Laboratory
2021.7-2023.8 Postdoctoral Research Fellow OuJiang Laboratory and Wenzhou Medical University
2017.6-2021.6 Postdoctoral Research Fellow Department of Basic Medicine, Tianjin Medical University
Dr. Wang and his team focus primarily on investigating the pathogenesis of Alzheimer's disease (AD). Employing cutting-edge techniques including genetics, epigenetics, three-dimensional genomics, and CRISPR technology, they explore the molecular mechanisms underlying Alzheimer's disease from the perspective of genomic non-coding regions, thereby providing novel insights for AD prevention and treatment strategies. Dr. Wang has published nearly 30 research papers in prestigious journals including Cell Genomics, Nature Communications, Genome Biology, Cell Discovery, and Nucleic Acids Research.
His research interest include:
1. The role and molecular mechanisms of genomic non-coding region variations in AD pathogenesis and other complex diseases.
2. Utilizing CRISPR technology to identify key molecules affecting AD onset and elucidate underlying molecular pathogenic mechanisms.
3. the mechanistic roles of immune and inflammatory-related molecules in AD pathogenesis and exploring their potential for targeted therapeutic interventions.
4. The mechanisms by which mitochondrial metabolism-related molecules contribute to AD pathogenesis and assessing their therapeutic targeting potential.
2023 Wenzhou "Ouyue Talent Plan" Technology Leading Talents
2024 Zhejiang Provincial Natural Science Foundation Outstanding Youth Fund Recipient
1. Wang, Z.*,#, Liang, Q.*, Qian, X.*, Hu, B.*, Zheng, Z., Wang, J., Hu, Y., Bao, Z., Zhao, K., Zhou, Y., Feng, X., Yi, X., Li, J., Shi, J., Liu, Z., Hao, J., Chen, K., Yu, Y., Sham, P.C., Lu, W., Wang, X.#, Song, W.# & Li, M.J#. An autoimmune pleiotropic SNP modulates IRF5 alternative promoter usage through ZBTB3-mediated chromatin looping. Nat Communications 14, 1208 (2023). (First and corresponding author, IF =16.6; highlighted by Nature Reviews Rheumatology, PMID: 37012360, IF = 33.7)
2. Wang, Z.*,#, Luo, M.*, Liang, Q.*, Zhao, K., Hu, Y., Wang, W., Feng, X., Hu, B., Teng, J., You, T., Li, R., Bao, Z., Pan, W., Yang, T., Zhang, C., Li, T., Dong, X., Yi, X., Liu, B., Zhao, L., Li, M., Chen, K., Song, W.#, Yang, J.# & Li, M.J#. Landscape of enhancer disruption and functional screen in melanoma cells. Genome Biology 24, 248 (2023). (First and corresponding author, IF = 12.3)
3. Wang, Z., Cai, W. & Song, W. CHIT1-positive microglia act as culprits for spinal motor neuron aging. Sci China Life Sci 67(4):847-848 (2024). (First author, IF = 9.5)
4. Zhao, K.*, Zhou, Y.*, Wang, X.*, Wang, Z.*, Xu, X., Chen, Y., Zhao, L., Wu, C., Wang, J., Yao, H., Cheng, X., Wang, W., Chu, X., Wang, W., Yi, X., Chen, Y., Li, M., Lu, W., Chen, K., Sham, P.C., Huang, D., Zhang, J. & Li, M.J. Endogenous fine-mapping and prioritization of functional regulatory elements in complex genetic loci. Cell Genomics, 100982 (2025). (Co-first author, IF = 11.1)
5. Dai, H., Chu, X., Liang, Q., Wang, M., Li, L., Zhou, Y., Zheng, Z., Wang, W.,Wang, Z., Li, H., Wang, J., Zheng, H., Zhao, Y., Liu, L., Yao, H., Luo, M., Wang, Q., Kang, S., Li, Y., Wang, K., Song, F., Zhang, R., Wu, X., Cheng, X., Zhang, W., Wei, Q., Li, M.J. & Chen, K. Genome-wide association and functional interrogation identified a variant at 3p26.1 modulating ovarian cancer survival among Chinese women. Cell Discovery. 2021; 7, 121. (IF = 33.5)
6. Zhang, S., He, Y., Liu, H., Zhai, H., Huang, D., Yi, X., Dong, X., Wang, Z., Zhao, K., Zhou, Y., et al. (2019). regBase: whole genome base-wise aggregation and functional prediction for human non-coding regulatory variants. Nucleic Acids Research. 47, e134. (IF = 14.9)
7. Wang, J., Huang, D., Zhou, Y., Yao, H., Liu, H., Zhai, S., Wu, C., Zheng, Z., Zhao, K., Wang, Z., et al. (2020). CAUSALdb: a database for disease/trait causal variants identified using summary statistics of genome-wide association studies. Nucleic Acids Research. 48, D807-D816. (IF = 14.9)
8. Zheng, Z., Huang, D., Wang, J., Zhao, K., Zhou, Y., Guo, Z., Zhai, S., Xu, H., Cui, H., Yao, H., Wang, Z., et al. (2020). QTLbase: an integrative resource for quantitative trait loci across multiple human molecular phenotypes. Nucleic Acids Research. 48, D983-D991. (IF = 14.9)
