tantao@ojlab.ac.cn
September 2005 – July 2008
Bachelor’s Degree: Department of Biology, Central China Normal University/China, Bachelor of Biology
September 2008 – July 2013
Doctoral Degree: Department of Biomedical Engineering, Tianjin Medical University/China
July 2013 – January 2014
Children’s Hospital of Chongqing Medical University/China, Assistant Researcher
January 2014 – May 2016
Children’s Hospital of Chongqing Medical University/China, Postdoc
May 2016 – May 2019
The State University of New York at Buffalo, Postdoc
May 2019 – July 2020
The State University of New York at Buffalo, Research Scientist
July 2020 – December 2021
Texas A&M University, Research Scientist
December 2021 – March 2023
Researcher, Wenzhou Medical University
April 2022 – Present
Associate Dean, School of Pharmacy, Wenzhou Medical University
Researcher TanTao and his team mainly focuses on exploring the circuit and synaptic mechanisms of neural developmental diseases (autism, schizophrenia, stress) addictive disorders (alcohol and drug), degenerative diseases (Alzheimer’s Disease), and trying novel non-invasive neuronal modulation strategies (repetitive transcranial magnetic stimulation, rTMS) on treating these diseases. Specifically, I investigate the synaptic action of various neuromodulators that are linked to mental disorders, including disease susceptibility genes and stress.
The major techniques include electrical physiology (Patch-seq, whole-cell patch-clamp recordings of ion channel and synaptic transmission, multi-channel in vivo single-unit recording on the free-moving animal), viral-based in vivo gene transfer, whole-brain trapping, and circuit mapping, two-photon, biochemical and immunocytochemical detection of synaptic proteins (PCR, WB, Co-IP), in vivo/in vitro chemo-genetics and optogenetic manipulation of neuronal circuits, bulk and single-cell RNA-seq (SMART-seq2 and SMART-seq3, ATAC-seq), behavioral assays and non-invasive treatment (rTMS, tDCS).
Awards：
1.Selected for the Ministry of Education's Overseas Talent Recruitment Program (Overseas Postdoctoral Return Program) (First Batch of the Ministry of Education's Talent Recruitment Plan);
2.Selected for the Provincial High-level Overseas Talent Introduction Program (Young Project);
3.Member of the Stress Neurobiology Branch of the Chinese Neuroscience Society;
4.Member of the Neural Regeneration and Repair Professional Committee of the Chinese Society of Research Hospitals;
5.Member of the Society for Neuroscience (USA), the Chinese Neuroscience Society, and the Zhejiang Neuroscience Society.
6.Serves as an editorial board member for Frontiers in Behavioral Psychiatry and other journals, and a reviewer for SCI journals such as Research.
7. Combined with non-invasive neural regulation using magnetic nanoparticles and its application in anxiety, 2024 First "Tech Innovation Cup" Medical Device Innovation and Application Skills Competition, Second Prize, China Technology Market Association
Funding：
1) National Natural Science Foundation of China - General Project, Research on the Gender Differences in Violence/Depression Caused by Adolescent Stress and the BNST and Circuit Mechanisms (82471536), 2025-2028, In progress
2) National Natural Science Foundation of China - Youth Science Foundation (Class C), Research on the Cortical-Thalamic Circuit Mechanism Caused by Ctnnb1 Deficiency during Neurodevelopment Leading to Cognitive Impairment (32500517), 2026-2028, In progress (Team Member: Wang Wei)
3) Overseas Recruitment Special Project of the Ministry of Education, Research on the Pathogenic Mechanism of Autism High-Risk Genes and Non-Invasive Intervention, 2024-2026, In progress
4) Wenzhou Ou Yue Innovation Team, Innovation Team on Stress Response and Mental Health (2024R2002), 2025-2027, In progress
5) Wenzhou Major Scientific Innovation Project, Research on the Precision Diagnosis and Treatment Markers of Schizophrenia Based on Integrated Biology and Mechanism Study (ZY2023006), 2024-2026, In progress
6) Oujiang Laboratory Start-up Project, Research on the Pathogenic Mechanism of Autism High-Risk Genes and Non-Invasive Intervention (OJQD2022002), 2022-2027, In progress
7) Horizontal Project, Safety Experiment of Low Intensity Pulsed Ultrasound Neural Regulation (OJHX202401), 202501-202512, In progress
8) National Natural Science Foundation of China - Youth Science Foundation, Research on the Synaptic Plasticity Mechanism of rTMS in Regulating Cognitive Function of AD, 2015-2017, Completed
9) Children's Hospital of Chongqing Medical University Outstanding Young Talent Plan B Class, Research on the Mechanism of rTMS in Regulating Autism, 2015-2016, Completed
10) The 56th Batch of National Postdoctoral Science Foundation Face-to-Face Funding for "Western Region Postdoctoral Talent Support Program", Research on the Synaptic Plasticity Mechanism of rTMS in Regulating Cognitive Function of AD, 2014-2016, Completed
11) 2014 "Special Funding for Postdoctoral Research Projects of Chongqing" Project, Research on the Synaptic Plasticity Mechanism of rTMS in Regulating Cognitive Function of AD, 2014-2016, Completed
12) Doctoral Innovation Fund of Tianjin Medical University "211 Project", Research on the Mechanism of rTMS in Repairing Memory Damage in Aβ Model Rats, 2010-2013, Completed
1) Jingyao Gao, Jie Yang, Shumin Wu, Tong Ye, Li Huang, Wei Wang, Tao Tan*. (2025) The Development and Prospect of Chemogenetics in Neuroscience: DREADD and Ligands. Molecular Psychiatry. (accept),（通讯作者）
2) Gao J†, Wu S†, Yang J, Ye T, Yang J, Shen W, Chen X, Huang L, Pang R, Lin P, Lin J, Zhou Y, Wang W, Tan T*. Comprehensive behavioral characterization and impaired hippocampal synaptic transmission in R1117X Shank3 mutant mice. Translational Psychiatry. 2025 Aug 9;15(1):274. doi: 10.1038/s41398-025-03505-1. (中科院2区，IF 6.2)，（通讯作者）
3) Liu S, Liu X, Duan Y, Huang L, Ye T, Gu N*, Tan T*, Zhang Z*, Sun J*. (2025). PIEZO2 is the underlying mediator for precise magnetic stimulation of PVN to improve autism-like behavior in mice. Journal of Nanobiotechnology. 2025 Jul 8;23(1):494. doi: 10.1186/s12951-025-03557-x. (中科院1区，IF 12.6)，（通讯作者）
4) Luo Q, Ye X, Xu J, Sun Z, Wang P, Chen H, Gao T, Deng Q, Wang Z, Wang Q, Chen X, Zhao Z, Wu Y, Yang C, Lyv W, Lyv X, Li Y, Zhao H, Jiang K, Gu Z, Lin J, Sun Y, Tan T*, Xu H*, Tong Z*. (2025). Low-intensity pulsed ultrasound enhances delivery of 30 nm Q10 for improving mental and memory disorder in APP/PS1 mice. Drug Delivery and Translational Research. 2025 Feb 24. doi: 10.1007/s13346-025-01814-y. (中科院2区，IF 5.7)，（通讯作者）
5) Ni T†, Sun Y†, Li Z†, Tan T†, Han W, Li M, Zhu L, Xiao J, Wang H, Zhang W, Ma Y, Wang B, Wen D, Chen T, Tubbs J, Zeng X*, Yan J*, Gui H*, Sham P, Guan F*. (2025). Integrated Transcriptome Analysis Reveals Novel Molecular Signatures for Schizophrenia Characterization. Advanced Science. 2025 Jan;12(2):e2407628. doi: 10.1002/advs.202407628. (中科院1区，IF 14.1)，（第一/共同第一作者文章）
6) Tan T, Wang W, Liu T, Zhong P, Conrow-Graham M, Tian X, Yan Z*. (2021). Neural circuits and activity dynamics underlying sex-specific effects of chronic social isolation stress. Cell Reports. 2021 Mar 23;34(12):108874. doi: 10.1016/j.celrep.2021.108874. (中科院1区，IF 9.99)，（第一/共同第一作者文章）
7) Tan T, Wang W, Williams J, Ma K, Cao Q, Yan Z*. (2019). Stress Exposure in Dopamine D4 Receptor Knockout Mice Induces Schizophrenia-Like Behaviors via Disruption of GABAergic Transmission. Schizophrenia bulletin. 2019 Sep 11;45(5):1012-1023. doi: 10.1093/schbul/sby163. (中科院1区，IF 7.9)，（第一/共同第一作者文章）
8) Rapanelli M†, Tan T†, Wang W, Wang X, Wang ZJ, Zhong P, Frick L, Qin L, Ma K, Qu J, Yan Z*. (2021). Behavioral, circuitry, and molecular aberrations by region-specific deficiency of the high-risk autism gene Cul3. Molecular Psychiatry. 2021 May;26(5):1491-1504. doi: 10.1038/s41380-019-0498-x. (中科院1区，IF 15.9)，（第一/共同第一作者文章）
