Education

2003-2009 Fudan University, Ph.D.

1999-2003 Fudan University, B.S.

 

Academic Experience

2023-present PI/Professor, Oujiang Laboratory

2016-2022 PI/Professor, Zhongshan Ophthalmic Center, Sun Yat-sen University

2012-2016 Research Associate, Department of Biology, University of Maryland, College Park

2010-2011 Research Associate, Department of Ophthalmology, Northwestern University

2009-2010 Research Associate, Department of Pharmacology, University of Virginia

 

Overview of Academic Research

Throughout his career, Dr. Ke has been deeply engaged in the field of visual neurobiology, dedicated to exploring how the retina processes visual information precisely under normal conditions, and further probing the pathogenesis, as well as possible diagnosis and treatment methods of retinal diseases by studying the structural and functional abnormalities under diseased conditions. To date, he has published multiple academic papers in high-impact international journals, such as Neuron, The Journal of Neuroscience, Cell Reports, and eLife.

 

Major research interests:

1. The regulatory mechanisms of mammalian night vision;

2. The distribution and functions of adrenergic receptors in the retina as well as the application of related drugs in retinal diseases;

3. The differences in susceptibility and resilience of various visual signaling pathways to retinal diseases and their underlying mechanisms;

4. The mechanisms and regulation of Müller glial cell activation under retinal disease conditions.

 

Major Honor and Awards

2016 Hundred Talents Program (Sun Yat-sen University)

 

Representative Research Achievements

1. Zhang G^#, Liu JB^#, Yuan HL, Chen SY, Singer JH, Ke JB*. Multiple calcium channel types with unique expression patterns mediate retinal signaling at bipolar cell ribbon synapses. The Journal of Neuroscience, 2022, 42(34): 6487-6505.

2. Tang FS^#, Yuan HL^#, Liu JB, Zhang G, Chen SY, Ke JB*. Glutamate transporters EAAT2 and EAAT5 differentially shape synaptic transmission from rod bipolar cell terminals. eNeuro, 2022, 9(3): ENEURO.0074-22.2022.

3. Liang CQ^#, Zhang G^#, Zhang L, Chen SY, Wang JN, Zhang TT, Singer JH*, Ke JB*. Calmodulin bidirectionally regulates evoked and spontaneous neurotransmitter release at retinal ribbon synapses. eNeuro, 2021, 8(1): ENEURO.0257-20.2020.

4. Park SJH^#, Lieberman EE^#, Ke JB, Rho N, Ghorbani P, Rahmani P, Jun AY, Lee HL, Kim IJ, Briggman KL, Demb JB*, Singer JH*. Connectomic analysis reveals an interneuron with an integral role in the retinal circuit for night vision. eLife, 2020, 9: e56077.

5. Mortensen LS^#, Park SJH^#, Ke JB, Cooper BH, Zhang L, Imig C, Lowel S, Reim K, Brose N, Demb JB, Rhee JS*, Singer JH*. Complexin 3 increases the fidelity of signaling in a retinal circuit by regulating exocytosis at ribbon synapses. Cell Reports, 2016, 15(10): 2239-50.

6. Ke JB^#, Wang YV^#, Borghuis BG, Cembrowski MS, Riecke H, Kath WL, Demb JB*, Singer JH*. Adaptation to background light enables contrast coding at rod bipolar cell synapses. Neuron, 2014, 81(2): 388-401. Highlighted by Neuron

7. Mehta B^#, Ke JB^#, Zhang L, Baden AD, Markowitz AL, Nayak S, Briggman KL, Zenisek D*, Singer JH*. Global Ca²⁺ signaling drives ribbon-independent synaptic transmission at rod bipolar cell synapses. The Journal of Neuroscience, 2014, 34(18): 6233-6244.