caifang@ojlab.ac.cn
1995- 1999 B.D., Biology, Department of Biology, Hunan Normal University,
1999- 2004 Ph.D., Genetics, National Lab of Medical Genetics of China, Central South University
2005.01-2007.12 Visiting Scholar The University of British Columbia
2008.01-2011.09 Postdoctoral The University of British Columbia
2011.10-2023.05 Research Associate The University of British Columbia
2023.06-now Research Fellow Oujiang Laboratory
Prof. Cai has conducted research at the University of British Columbia, Canada. And joining Oujiang Laboratory since July 2023. She focused on the underline mechanisms of Alzheimer's disease and therapy. Her recent work has been published in the Journal of Clinical Investigation, Molecular Psychiatry, Signal Transduction and Targeted Therapy, and other journals. She has chaired or participated in several grants including the National Natural Science Foundation of China, Canadian Institutes of Health Research.
2005 National Award for Science and Technology Progress（Second prize）
1. Zhang J*, Cai F*, Lu R, Xing X, Xu L, Wu K, Gong Z, Zhang Q, Zhang Y, Xing M, Li J, Song W. CNTNAP2 intracellular domain (CICD) generated by γ-secretase cleavage improves autism-related behaviors. Signal Transduction and Targeted Therapy. 2023 Jun 5;8(1):219.
2. Cai F*, Song B*, Yang Yi, Liao H, Li R, Wang Z, Cao R, Chen H, Wang J, Wu Y, Zhang Y, Song W. USP25 contributes to defective neurogenesis and cognitive impairments. The FASEB Journal. 2023 Jun;37(6):e22971.
3. Zheng Q*, Song B*, Li G*, Cai F*, Wu M, Zhao Y, Jiang L, Guo T, Shen M, Hou H, Zhou Y, Zhao Y, Di A, Zhang L, Zeng F, Zhang XF, Luo H, Zhang X, Zhang H, Zeng Z, Huang TY, Dong C, Qing H, Zhang Y, Zhang Q, Wang X, Wu Y, Xu H, Song W, Wang X. USP25 inhibition ameliorates Alzheimer's pathology through the regulation of APP processing and Aβ generation. The Journal of Clinical Investigation. 2022 Mar 1;132(5):e152170.
4. Zhang S*, Cai F*, Wu Y*, Bozorgmehr T, Wang Z, Zhang S, Huang D, Guo J, Shen L, Rankin C, Tang B, Song W. A presenilin-1 mutation causes Alzheimer disease without affecting Notch signaling. Molecular Psychiatry. 2020 Mar;25(3):603-613.
5. Wang Z*, Xu Q*, Cai F*, Liu X, Wu Y, Song W. BACE2, a conditional β-secretase, contributes to Alzheimer's disease pathogenesis. JCI Insight. 2019 Jan 10;4(1):e123431.
