Saverio.Bellusci@innere.med.uni-giessen.de
1990-1991 Diplomed’Etudes Approndies (DEA) on "Proteins". Pasteur Institute
1991-1994 Graduate Program Biochemistry- University Paris VII
PROFESSIONAL CAREER | |
2014 - | Adjunct Professor, Wenzhou Medical University, China |
2010 - | W3 Professor, ECCPS, Justus Liebig University, Giessen |
2002 - 2010 | Assistant then Associate Professor of Developmental Biology and Regenerative Medicine, Childrens Hospital Los Angeles, California |
1998 - 2002 | Staff Scientist INSERM, Group leader in the UMR144/Institute Curie, France |
1995 –1997 | Postdoctoral training, Vanderbilt University, Nashville, Tennessee, USA (Brigid Hogan) |
MEMBERSHIP OR OFFICES HELD IN LEARNED SOCIETIES AND PROFESSIONAL BODIES | |
2023 – | Visiting professor at the Oujiang laboratories/Wenzhou Medical University, Zhejiang, China |
2020 – | Faculty Member of International Max Planck Research School (IMPRS) |
2012 – | Editorial Board Member Frontiers, BMC Biology, PLoS One Area leader (Area C - Angiogenesis and Alveogenesis) of the “Excellence Cluster Cardio-Pulmonary System” Faculty Member of the German Center for Lung Research (DZL) |
2011 – | Faculty Member of the Excellence Cluster Cardio-Pulmonary System (ECCPS) |
2011 –2022 | Visiting professor at Children Hospital Los Angeles, University of Southern California, USA |
2010 – | Faculty Member of the Universities Giessen and Marburg Lung Center (UGLMC) |
Reviewing Panel | Cell Reports, American Journal of Respiratory Cell and Molecular Biology, American Journal of Respiratory and Critical Care Medicine, European Respiratory Journal, PLoS One, American Journal of Physiology (Lung Cellular and Molecular Physiology), Development, Development Biology, Nature Genetics, PLoS Genetics, Cell Stem Cell and others |
Prof. Saverio Bellusci's research focuses on the mechanisms of lung development and regeneration, with particular attention to the roles of fibroblast growth factors and stem cells in lung development and regeneration.
His research interest include:
1. Pulmonary hypertension: To study the vascular remodeling mechanism of pulmonary hypertension and develop its potential treatment. To study the protective effect of growth factor on pulmonary hypertension and its mechanism.
2. Repair after pulmonary fibrosis injury: To study the mutual transformation of myofibroblast and lipofibrobalst in pulmonary fibrosis.
3. Bronchopulmonary dysplasia: A mouse model was used to study neonatal bronchopulmonary dysplasia and investigate the potential therapeutic effects of growth factors in BPD.
2018 Award for stem cell research from the Royan Institute, Teheran, Iran
2018 Award for Outstanding Collaboration, Wenzhou University, Zhejiang, China
1、Hadzic S, Wu CY, Gredic M, Pak O, Loku E, Kraut S, Kojonazarov B, Wilhelm J,
Brosien M, Bednorz M, Seimetz M, Günther A, Kosanovic D, Sommer N, Warburton D,
Li X, Grimminger F, Ghofrani HA, Schermuly RT, Seeger W, El Agha E, Bellusci S,
Weissmann N. Fibroblast growth factor 10 reverses cigarette smoke- and elastase-
induced emphysema and pulmonary hypertension in mice. Eur Respir J. 2023 Nov
9;62(5):2201606.
2、 Lingampally A, Truchi M, Mauduit O, Delcroix V, Vasquez-Pacheco E, Gautier-
Isola M, Chu X, Khadim A, Chao CM, Zabihi M, Taghizadeh S, Rivetti S, Marega M,
Moiseenko A, Hadzic S, Vazquez-Armendariz AI, Herold S, Günther S, Millar-
Büchner P, Koepke J, Samakovlis C, Wilhelm J, Bartkuhn M, Braun T, Weissmann N,
Zhang J, Wygrecka M, Makarenkova HP, Günther A, Seeger W, Chen C, El Agha E,
Mari B, Bellusci S. Evidence for a lipofibroblast-to-Cthrc1+
myofibroblast reversible switch during the development and resolution of lung
fibrosis in young mice. Eur Respir J. 2025 Feb 6;65(2):2300482.
3、 El Agha E, Kramann R, Schneider RK, Li X, Seeger W, Humphreys BD, Bellusci S.
Mesenchymal Stem Cells in Fibrotic Disease. Cell Stem Cell. 2017 Aug
3;21(2):166-177.
4、 Wasnick R, Korfei M, Piskulak K, Henneke I, Wilhelm J, Mahavadi P, Dartsch
RC, von der Beck D, Koch M, Shalashova I, Weiss A, Klymenko O, Askevold I, Fink
L, Witt H, Hackstein H, El Agha E, Bellusci S, Klepetko W, Königshoff M,
Eickelberg O, Schermuly RT, Braun T, Seeger W, Ruppert C, Guenther A. Notch1
Induces Defective Epithelial Surfactant Processing and Pulmonary Fibrosis. Am J
Respir Crit Care Med. 2023 Feb 1;207(3):283-299.
5、hu X, Kheirollahi V, Lingampally A, Chelladurai P, Valasarajan C, Vazquez-
Armendariz AI, Hadzic S, Khadim A, Pak O, Rivetti S, Wilhelm J, Bartkuhn M,
Crnkovic S, Moiseenko A, Heiner M, Kraut S, Atefi LS, Koepke J, Valente G,
Ruppert C, Braun T, Samakovlis C, Alexopoulos I, Looso M, Chao CM, Herold S,
Seeger W, Kwapiszewska G, Huang X, Zhang JS, Pullamsetti SS, Weissmann N, Li X,
El Agha E, Bellusci S. GLI1+ Cells Contribute to Vascular Remodeling in
Pulmonary Hypertension. Circ Res. 2024 May 24;134(11):e133-e149.
6、Kheirollahi V, Wasnick RM, Biasin V, Vazquez-Armendariz AI, Chu X, Moiseenko
A, Weiss A, Wilhelm J, Zhang JS, Kwapiszewska G, Herold S, Schermuly RT, Mari B,
Li X, Seeger W, Günther A, Bellusci S, El Agha E. Metformin induces lipogenic
differentiation in myofibroblasts to reverse lung fibrosis. Nat Commun. 2019 Jul
5;10(1):2987.
7、Truchi M, Gautier-Isola M, Savary G, Scribe C, Lingampally A, Cadis H, Baeri
A, Magnone V, Girard-Riboulleau C, Arguel MJ, de Schutter C, Fassy J, Boukrout
N, Larrue R, Martin N, Rezzonico R, Pluquet O, Perrais M, Hofman V, Marquette
CH, Hofman P, Günther A, Ricard N, Barbry P, Leroy S, Lebrigand K, Bellusci S,
Cauffiez C, Vassaux G, Pottier N, Mari B. Aging affects reprogramming of
pulmonary capillary endothelial cells after lung injury in male mice. Nat
Commun. 2025 Aug 6;16(1):7234.
8、Chao CM, Bellusci S, Zepp JA. p16INK4a and the Alveolar
Niche Take Center Stage in Bronchopulmonary Dysplasia. Am J Respir Crit Care
Med. 2020 Oct 15;202(8):1065-1067.
