linli@wmu.edu.cn
2009-2014 | Nanjing University of Science and Technology | Doctor |
2002-2005 | East China Normal University | Master |
1990-1994 | East China Normal University | Bachelor |
2024 – Present | Member of the CPC Committee | Wenzhou Medical University |
2020 – Present | Dean of the School of Pharmacy | Wenzhou Medical University |
2010 – Present | Professor | Wenzhou Medical University |
2015-2016 | Postdoctor | Harvard Medical School |
2005—2010 | Associate Professor | Wenzhou Medical University |
2000—2005 | Lecturer | Wenzhou Medical University |
1994—2000 | Teaching Assistant | Wenzhou Medical University |
Professor Lin and her team have been dedicated to addressing critical challenges in the field of central nervous system (CNS) diseases and regenerative medicine. Her major research focus is on innovative drug discovery and the clinical translation of growth factor mechanisms for CNS repair and regenerative medicine. She has conducted pioneering work in elucidating the roles of FGF/FGFR signaling in brain development and function, utilizing advanced technologies such as 3D brain atlasing, ultra-high-speed light-sheet imaging, and single-cell sequencing. Additionally, she has developed novel therapeutic strategies for neurological disorders, including stroke, traumatic brain injury, and Alzheimer's disease. Her work explores how fibroblast growth factors (FGFs) shape neurological disorders, their potential to restore neural function, and the foundation they provide for future clinical therapies.
Her research interests include:
1. High-definition FGFs distribution in the CNS and action loop in the neural circuits;
2. Mechanisms and clinical translation of FGFs in CNS diseases;
3. Smart brain-targeted delivery of FGFs for CNS repair and novel drug discovery.
2022 Provincial “Ten-Thousand Talents Program” Distinguished Teaching Scholar,
2020 National High-Level Talents Program (“Hundred-Thousand-Ten Thousand Talents Project”)
2020 Award for Outstanding Young and Middle-Aged Experts
2018 State Science and Technology Progress Award (Second Prize)
2016 Zhejiang Provincial Medical and Health Science and Technology Award (Second Prize)
2014 Zhejiang Provincial Education Achievement Award (Second Prize)
2007 Zhejiang Provincial Higher Education Institutions Scientific and Technological Achievement Award (Third Prize)
1. Lei Zhang, Peng Zhang, Guangfu Wang, Huaye Zhang, Yajun Zhang, Yilin Yu, Mingxu Zhang, Jian Xiao, Piero Crespo, Johannes W Hell, Li Lin*, Richard L Huganir, J Julius Zhu. Ras and rap signal bidirectional synaptic plasticity via distinct subcellular microdomains. Neuron. 2018 Apr 26; 10.1016/j.neuron.
2. Li Lin*, Smriti Gupta , W Sharon Zheng , Ke Si , J Julius Zhu. Genetically encoded sensors enable micro- and nano-scopic decoding of transmission in healthy and diseased brains. Molecular Psychiatry. 2020 Dec 4; s41380-020-00960-8.
3. Bixin Shen, Junhui Wang, Tao He, Shihao Chen, Xue Wang, Jun Chen, Ruiqing Shi, Jing Wang, Hao Wang, Wenting Huang, Chengkun Cao, Xianxi Tan*, Jutaek Nam*, Li Lin*. Ultrasoft bioadhesive hydrogel as a versatile platform for the delivery of basic fibroblast growth factor to repair traumatic brain injury. Chemical Engineering Journal. 2024 March 1; 10.1016/j.cej.
4. Bo Xing , Nancy R Mack , Kai-Ming Guo , Yu-Xiang Zhang , Billy Ramirez , Sha-Sha Yang , Li Lin* , Dong V Wang , Yan-Chun Li , Wen-Jun Gao*. A subpopulation of prefrontal cortical neurons is required for social memory. Biological Psychiatry. 2021 Mar 1; 10.1016/j.biopsych.
5. Confidence Dordoe , Wenting Huang , Canol Bwalya , Xue Wang , Bixin Shen , Hao Wang , Jing Wang , Shasha Ye , Peng Wang , Bao Xiaoyan , Xiaokun Li*, Li Lin*. The role of microglial activation on ischemic stroke: Modulation by fibroblast growth factors. Cytokine & Growth Factor Reviews. 2023 Jul 31; 10.1016/j.cytogfr.
6. Xiaoyan Bao, Kang Qian , Mengjiao Xu , Yi Chen , Hao Wang , Ting Pan , Zhengyi Wang , Ping Yao*, Li Lin*. Intestinal epithelium penetration of liraglutide via cholicacid pre-complexation and zein/rhamnolipids nanocomposite delivery. Journal of Nanobiotechnology. 2023 Jan 16; s12951-022-01743-9.
7. Dongxue Wang, Fei Liu, Liyun Zhu, Ping Lin, Fanyi Han, Xue Wang, Xianxi Tan, Li Lin*, Ye Xiong*. FGF21 alleviates neuroinflammation following ischemic stroke by modulating the temporal and spatial dynamics of microglia/macrophages. Journal of Neuroinflammation. 2020 Aug 31; s12974-020-01921-2.
8. Mengmeng Ma , Jing Wang , Hao Jiang , Qiushui Chen , Yi Xiao*, Huanghao Yang*, Li Lin*.Transcranial deep-tissue phototherapy for Alzheimer’s disease using low-dose X-ray-activated long-afterglow scintillators. Acta Biomaterialia. 2023 Jan 1; 10.1016/j.actbio.
