chenjf555@gmail.com
1987-1993 Pennsylvania Medical College Ph.D.
1983-1986 Third Military Medical University M.S.
1978-1983 Wenzhou Medical College M.B.
2022- present professor with a joint appointment Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health)
2016-present Professor Affiliated Ophthalmology Hospital, Wenzhou Medical University
2010-2015 Professor Department of Neurology, Medical College, Boston University
2001 -2010 Associate Professor Department of Neurology, Medical College, Boston University
1996-2001 lecturer Department of Neurology, Massachusetts General Hospital, Harvard Medical School
1994-1996 postdoctoral fellow Harvard Medical School (Department of Neurology, Massachusetts General Hospital)
Committed to the molecular pharmacology of adenosine receptors for more than 26 years;
Multiple key and important contributions in establishing A2A receptor as a non-dopaminergic target for treating Parkinson's disease;
Participating in the development of clinical drugs for A2A receptor antagonists for Parkinson's disease for 20 years as a scientific consultant, which was approved by the US FDA in September 2019;
Publishing more than 250 papers in Nature Medicine, PNAS, Molecular Psychology and other publications, which have been cited more than 21000 times, with an H factor of 81.
His research interest include:
1. the structural basis of the integration of visual function and brain function
2. Molecular and loop mechanisms of light-controlled visual development and brain function.
3. Early diagnosis and treatment of neuropsychiatric diseases targeting retina.
2016 National Natural Science Foundation of China, General Program
2017 Key projects of National Natural Science Foundation of China
2021 National Natural Science Foundation of China, Original Exploration Project
2021 National Natural Science Foundation of China, Research Fund for International Senior Scientists
2023 Key R&D projects in Zhejiang Province
2024 Key projects of National Natural Science Foundation of China
Awards
● 2012: Zhejiang Provincial "Qianjiang Scholars" Distinguished Professor
1.Zhou Xuzhao, He Yan, Xu Tao, Wu Zhaofa, Guo Wei, Xu Xi, Liu Yuntao, Zhang Yi, Shang Huiping, Huang Libin, Yao Zhimo, Li Zewen, Su Lingya, Li Zhihui, Feng Tao, Zhang Shaomin, Monteiro Olivia, Cunha Rodrigo A, Huang Zhi-Li, Zhang Kang*, Li Yulong, Cai Xiaohong*, Qu Jia*, Chen Jiang-Fan*. 40 Hz light flickering promotes sleep through cortical adenosine signaling. Cell Res. 2024;34(3):214-231.
2.Xiaoting Sun, Liliana Dias, Chenlei Peng, Ziyi Zhang, Haoting Ge, Zejun Wang, Jiayi Jin, Manli Jia, Tao Xu, Wei Guo,Wu Zheng, Yan He, Youru Wu, Xiaohong Cai, Paula Agostinho, Jia Qu, Rodrigo A. Cunha*, Xuzhao Zhou*, Ruiliang Bai* and Jiang-fan Chen*. 40 Hz light flickering facilitates the glymphatic flow via adenosine signaling in mice. Cell Discov. 2024 Aug 6;10(1):81.
3.Wang Muran, Li Peijun, Li Zewen, da Silva, Beatriz S, Zheng Wu, Xiang Zhenghua, He Yan, Xu Tao, Cordeiro Cristina, Deng Lu, Dai Yuwei, Ye Mengqian, Lin Zhiqing, Zhou Jianhong, Zhou Xuzhao, Ye Fenfen, Cunha Rodrigo A., Chen Jiangfan*, Guo Wei*. Lateral septum adenosine A2A receptors control stress-induced depressive-like behaviors via signaling to the hypothalamus and habenula. Nat Commun. 2023 Apr 5;14(1):1880.
4.Wu Zheng, Yijia Feng, Zhenhai Zeng, Mengqian Ye, Mengru Wang, Xin Liu, Ping Tang, Huiping Shang, Xiaoting Sun, Xiangxiang Lin, Muran Wang, Zhengzheng Li, Yiyun Weng, Wei Guo, Sergii Vakal, Jiang-Fan Chen*. Choroid plexus-selective inactivation of adenosine A2A receptors protects against T cell infiltration and experimental autoimmune encephalomyelitis .
Journal of Neuroinflammation, 2022 Feb 18; 19(1):52.
5.Jiang-Fan Chen, Holger K Eltzschig, Bertil B Fredholm*. Adenosine receptors as drug targets--what are the challenges? Nat Rev Drug Discov. 2013 Apr;12(4):265-86.
6. Liqun Yu, Zhihong Huang, Juliana Mariani, Yumei Wang, Michael Moskowitz, Jiang-Fan Chen*.Selective inactivation or reconstitution of adenosine A2A receptors in bone marrow cells reveals their significant contribution to the development of ischemic brain injury. Nat Med. 2004 Oct;10(10):1081-7.
