chenyaping@ojlab.ac.cn
2013-2017 Monash University Ph.D.
2008-2012 Wuhan University Bachelor
2023.11-present Principal Investigator (PI) Oujiang Laboratory
2022.10-2023.11 Senior Research Fellow Monash University
2018.10-2020.10 Visiting Scientist Commonwealth Scientific and Industrial Research Organisation (CSIRO)
2017.06-2022.10 Research Fellow Monash University
Dr. Yaping Chen is a Principal Investigator (PI) and Professor at Oujiang Lab, and a doctoral supervisor. She was selected for the National Young Talents Program (2021) and the Zhejiang Provincial Young Talents Program (2023). In November 2023, Dr. Chen joined the Oujiang Laboratory and established the Nano-Immuno Research Group. Her research focuses on integrating novel nanotechnologies, molecular biology, and immunology to develop efficient and precise nano-injection techniques, and exploring their applications and mechanisms in gene editing and cell-based therapies. Her research integrates novel nanotechnology with molecular biology and immunology to develop efficient and precise nanoinjection techniques and investigate their applications and mechanisms in gene editing and cell therapies. To date, Prof. Chen has published over 30 SCI-indexed papers in internationally renowned journals including Advanced Materials, Nature Protocols, Materials Today, Nature Medicine, Nature Immunology, and JACS. She has led seven research projects, including the Australian Research Council CTET Early Career Project, the Australia–Germany Joint Research Project, and a Monash Institute of Pharmaceutical Sciences commercial incubation project. She also holds two international patent applications. Dr. Chen serves as an invited reviewer for several academic journals (e.g., Adv. Funct. Mater., Sci. Adv.).
Her research interests include:
1. Nanodelievery technologies and cell transfection
2. Cellular immunotherapies (e.g., CAR-T)
3. Biomechanics-induced immune cell differentiation and functional regulation
4. Novel immunotherapies and other open research areas
2024 IAAM Scientist Medal (International Association of Advanced Materials
2023 Melbourne Biomedical Postdoctoral Association Best Speaker Award
2021 Monash Young Investigator Publication Award
2017 International Cytokine & Interferon Society (ICIS) Milstein Award
2016 DAAD Scholarship (Deutscher Akademischer Austauschdienst)
2015 Chinese Association of Biomedical Scientists (Australia) Young Investigator Award
1. Chen, Y.*; Shokouhi, A.-R.; Voelcker, N. H.*; Elnathan, R*. Nanoinjection: A Platform for Innovation in Ex Vivo Cell Engineering. Acc. Chem. Res. 2024, 57, 1722-1735.
2. Chen, Y.*, Mach, M.; Shokouhi, A.-R.; Yoh, H. Z.; Bishop, D. C.; Murayama, T.; Suu, K.; Morikawa, Y.; Barry, S. C.; Micklethwaite, K.*; et al. Efficient non-viral CAR-T cell generation via silicon-nanotube-mediated transfection. Mater. Today 2023, 63, 8-17.
3. Shokouhi,A.-R.; Chen, Y.*; Yoh, H. Z.; Brenker, J.; Alan, T.; Murayama, T.; Suu, K.; Morikawa, Y.; Voelcker*, N. H.; Elnathan, R*. Engineering Efficient Car-T Cells via Electroactive Nanoinjection. Adv. Mater. 2023, 2304122.
4. Chen, Y.; Aslanoglou, S.; Murayama, T.; Gervinskas, G.; Fitzgerald, L. I.; Sriram, S.; Tian, J.; Johnston, A. P. R.; Morikawa, Y.; Suu, K.; et al. Silicon-Nanotube-Mediated Intracellular Delivery Enables Ex Vivo Gene Editing. Adv. Mater. 2020, 32, 202000036.
5. Yoh, H. Z#; Chen, Y.#*; Aslanoglou, S.; Wong, S.; Trifunovic, Z.; Crawford, S.; Lestrell, E.; Priest, C.; Alba, M.; Thissen, H.; et al. Polymeric Nanoneedle Arrays Mediate Stiffness-Independent Intracellular Delivery. Adv. Funct. Mater. 2022, 32 (3), 2104828.
6. Chiappini, C.#*; Chen, Y.#; Aslanoglou, S.; Mariano, A.; Mollo, V.; Mu, H.; De Rosa, E.; He, G.; Tasciotti, E.; Xie, X.; et al. Tutorial: using nanoneedles for intracellular delivery. Nat. Protoc. 2021, 16 (10), 4539-456
7. Chen, Y.*; Yoh, H. Z.; Shokouhi, A.-R.; Murayama, T.; Suu, K.; Morikawa, Y.; Voelcker, N. H.*; Elnathan,* R. Role of actin cytoskeleton in cargo delivery mediated by vertically aligned silicon nanotubes. J. Nanobiotechnology 2022, 20 (1), 406.
8. Aslanoglou, S.#; Chen, Y.#; Oorschot, V.; Trifunovic, Z.; Hanssen, E.; Suu, K.; Voelcker, N. H.; Elnathan, R. Efficient TEM characterization of cell–nanostructure interfacial interactions. JACS 2020, 142 (37), 15649–15653.
