sh2ling@126.com；lingshukuan@ojlab.ac.cn
2010/03-2015/12, Department of Biomedical Engineering, School of Life Science and Technology, Harbin Institute of Technology, PhD
2004/09-2007/06, State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Master
2000/09-2004/06, Department of Biology, Qingdao University, Bachelor
2022.7- present Principal Investigator (PI) Director of Research Management Department, Oujiang Laboratory; Head of Special Environmental Medicine Research Laboratory,Oujiang Laboratory
2020.12-2022.6 Principal Investigator (PI) State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center
2017.12-2020.12 Associate Research Professor State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center
2009.12-2017.12 Associate Research Professor State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center
2011.8-2013.8 Visiting Scholar Department of Biochemistry, University of Texas Medical Branch, USA
Overview of Academic Research
Our long-term goal is to elucidate the molecular mechanisms underlying spaceflight-related medical challenges, with a particular focus on cardiovascular dysfunction and bone loss induced by microgravity. We are particularly interested in the following areas.
1. Mechanistic studies of aerospace medicine–related pathologies.
2. Molecular mechanisms of myocardial remodeling, with an emphasis on the regulatory roles of non-coding RNAs and ion channels.
3. Mechanosensing in bone tissue cells, investigated through mechanical models (altered gravity, shear stress, and soft/hard substrates) and validated in mouse models.
4. Therapeutic development targeting membrane proteins, focusing on small-molecule modulators of ion channels.
Our long-term goal is to elucidate the molecular mechanisms underlying spaceflight-related medical challenges, with a particular focus on cardiovascular dysfunction and bone loss induced by microgravity. We are particularly interested in the following areas.
1. Mechanistic studies of aerospace medicine–related pathologies.
2. Molecular mechanisms of myocardial remodeling, with an emphasis on the regulatory roles of non-coding RNAs and ion channels.
3. Mechanosensing in bone tissue cells, investigated through mechanical models (altered gravity, shear stress, and soft/hard substrates) and validated in mouse models.
4. Therapeutic development targeting membrane proteins, focusing on small-molecule modulators of ion channels.
2019 The National Science Fund for Excellent Young Scholars
2018 Third Prize, Military Scientific and Technological Progress Award – Research and Application of Aerospace Immunological Effects
2015 Beijing Nova Program in Science and Technology
1. Shi Z, Wang XM, Duan WW, Du YL, Ling SK, Zhang Z, Wang GD, Zhao D, Ding JJ, Zhang K, Li A, Yan L, Zhang Y, Cheng D, Huang TC, Xie WJ, Lin LM, Tuo QH, Xia BH, Yuan TF, Wu RR, Chen XF. Neuroplasticity and brain health: insights from natural torpor. Biol Rev Camb Philos Soc. 2025 Aug 27.
2. Li Y, Sun W, Li J, Du R, Xing W, Yuan X, Zhong G, Zhao D, Liu Z, Jin X, Pan J, Li Y, Li Q, Kan G, Han X, Ling S, Sun X, Li Y. HuR-mediated nucleocytoplasmic translocation of HOTAIR relieves its inhibition of osteogenic differentiation and promotes bone formation. Bone Res. 2023 Oct 23;11(1):53.
3. Sun W, Guo S, Li Y, Li J, Liu C, Chen Y, Wang X, Tan Y, Tian H, Wang C, Du R, Zhong G, Shi S, Ma B, Qu C, Fu J, Jin X, Zhao D, Zhan Y, Ling S, An H, Li Y. Anoctamin 1 controls bone resorption by coupling Cl- channel activation with RANKL-RANK signaling transduction. Nat Commun. 2022 May 24;13(1):2899.
4. Liu C, Gao X, Li Y, Sun W, Xu Y, Tan Y, Du R, Zhong G, Zhao D, Liu Z, Jin X, Zhao Y, Wang Y, Yuan X, Pan J, Yuan G, Li Y, Xing W, Kan G, Wang Y, Li Q, Han X, Li J, Ling S, Li Y. The mechanosensitive lncRNA Neat1 promotes osteoblast function through paraspeckle-dependent Smurf1 mRNA retention. Bone Res. 2022 Feb 24;10(1):18.
5. Zhao Y, Ling S, Li J, Zhong G, Du R, Li Y, Wang Y, Liu C, Jin X, Liu W, Liu T, Li Y, Zhao D, Sun W, Liu Z, Liu Z, Pan J, Yuan X, Gao X, Xing W, Chang YZ, Li Y. 3' untranslated region of Ckip-1 inhibits cardiac hypertrophy independently of its cognate protein. Eur Heart J. 2021 Sep 21;42(36):3786-3799.
6. Zhao D, Zhong G, Li J, Pan J, Zhao Y, Song H, Sun W, Jin X, Li Y, Du R, Nie J, Liu T, Zheng J, Jia Y, Liu Z, Liu W, Yuan X, Liu Z, Song J, Kan G, Li Y, Liu C, Gao X, Xing W, Chang YZ, Li Y, Ling S. Targeting E3 Ubiquitin Ligase WWP1 Prevents Cardiac Hypertrophy Through Destabilizing DVL2 via Inhibition of K27-Linked Ubiquitination. Circulation. 2021 Aug 31;144(9):694-711.
7. Li J, Liu C, Li Y, Zheng Q, Xu Y, Liu B, Sun W, Li Y, Ji S, Liu M, Zhang J, Zhao D, Du R, Liu Z, Zhong G, Sun C, Wang Y, Song J, Zhang S, Qin J, Ling S, Wang X, Li Y. TMCO1-mediated Ca2+ leak underlies osteoblast functions via CaMKII signaling. Nat Commun. 2019 Apr 8;10(1):1589.
8. Ling S, Sun Q, Li Y, Zhang L, Zhang P, Wang X, Tian C, Li Q, Song J, Liu H, Kan G, Cao H, Huang Z, Nie J, Bai Y, Chen S, Li Y, He F, Zhang L, Li Y. CKIP-1 inhibits cardiac hypertrophy by regulating class II histone deacetylase phosphorylation through recruiting PP2A. Circulation. 2012 Dec 18;126(25):3028-40.
